In rodents, ID, with or without anaemia, decreased serum T4 and T3 concentrations, lowered 5-deiodinase (DIO) activity and reduced the ability to thermoregulate in response to a cold environment ( Reference Hess, Zimmermann and Arnold 39 , Reference Beard, Tobin and Green 51 Reference Beard, Finch and Green 53 )
The ODT follows a titration schedule conceptually similar to the injectable version, starting low and escalating gradually
To deplete gut microbiota, animals received a cocktail of 100 g/mL neomycin, 50 g/mL streptomycin, 100 g/mL ampicillin, 50 g/mL vancomycin, 100 g/mL metronidazole, 1 mg/mL bacitracin, 125 g/mL ciprofloxacin, and 100 g/mL ceftazidime (Sigma-Aldrich) in the drinking water (69)
AHK-Cu peptide 1g is commonly studied in laboratory research for its copper-binding properties and peptide-related applications